Welcome to The trippier research Group
The Trippier lab utilizes bioorganic and medicinal chemistry combined with chemical biology to study problems at the interface of chemistry, biology, and medicine. Our ultimate goal is to develop new insights into the mechanisms of human disease and exploit this knowledge in the development of new therapeutics.
Nov 2018 - Congratulations to Ahmed on the publication of his paper on ABAD inhibitors for Alzheimer's Disease in the Journal of Medicinal Chemistry! Check out our publications page for more details.
Aug 2018 - Welcome to the new group members! Shafikur joined us as a graduate student while Myla and Andrew are pharmacy students getting their feet wet in medicinal chemistry research.
Aug 2018 - Congratulations to Nihar and our collaborators in the Boustany lab on the publication of a manuscript in the Annals of Clinical and Translational Neurology! This paper describes the effect of some of our neuroprotective compounds on caspase enzymes in a number of in vitro models of the neuronal ceroid lipofuscinoses. Check out our publications page for more details and a link to the open access article.
Jul 2018 - Welcome to Nauman Zia, a P1 student who will be carrying out research in the group to develop AKR1C3 inhibitors.
Jun 2018 - Congratulations to Verma and our long time collaborators, the Penning Lab at the University of Pennsylvania Perelman School of Medicine, on the publication of a manuscript in Molecular Cancer Therapeutics detailing the in vitro and in vivo activity of our AKR1C3 inhibitors as potential therapeutics for prostate cancer. Check out our publications page for more details.
May 2018 - May was a good month for patents and papers! Our first teaching paper was accepted into the Journal of Chemical Education analyzing the molecule of the month activity used in the introductory medicinal chemistry course at Tech. We also filed a provisional patent on our Complex II inhibitor work. Check out our publications page for more details.
May 2018 - Paul is a member of the P3 Teaching Team of the Year for the Neurology and Psychiatric Pharmacotherapy Course! Thanks P3 class.
Apr 2018 - Our review on the chemistry and pharmacology of methamphetamine for the special issue of ACS Chemical Neuroscience; DARK Classics in Chemical Neuroscience is online now. It was a very interesting process putting this paper together and hopefully it will be prove useful to the community! Check out our publications page for more details.
Jan 2018 - Welcome to new group members Angelica and Juan! Angelica is a first year graduate student and Juan has decided to stay with us to complete his Masters.
Jan 2018 - Congratulations to Verma who has accepted a position at Genentech in California!
Nov 2017 - Congratulations to Nihar who is now Dr. Kinarivala! November was a big month for him; thesis defense and a paper accepted to the Journal of Medicinal Chemistry. He will pursue postdoctoral studies with Prof. Derek Tan at Memorial Sloan Kettering Cancer Center in New York City.
Nov 2017 - Congratulations to Nihar whose manuscript detailing the synthesis and mechanism of action studies of neuroprotective aromatic carbamates has been accepted for publication in the Journal of Medicinal Chemistry! See our publication page for more details.
Nov 2017 - Congratulations to Kshitij who is now Dr. Verma! He successfully defended his thesis and becomes the first student to graduate from the Trippier lab!
Oct 2017 - The group has five presentations at the ACS Southwest Regional Meeting in a mixture of posters and talks. Check out SWRM 22, 156, 209, 213 & 215 to get an update on our research in cancer and neurodegenerative disease drug discovery and chemical biology.
Oct 2017 - Welcome to Juan Valdez, a Masters student who is completing a rotation through the lab.
Sep 2017 - Welcome to Andrew Baez who joins us as a graduate student working on the design of novel peptidomimetics for the potential treatment of stroke.
Sep 2017 - The lab is awarded a seed grant from the School of Pharmacy for a collaborative project with Dr. Vardan Karamyan to develop a hit compound with potential benefit for stroke therapy. Thanks TTUHSC Office of Sciences!
Aug 2017 - The lab is presenting at the ACS National Meeting in DC! Verma has a poster (MEDI Travel Award Recipient) describing our progress on development of selective AKR1C3 inhibitors on Monday night. Paul is presenting a talk on our efforts to develop therapeutics for neurodegenerative diseases as part of the Early Career Investigators Session (BIOL) on Monday afternoon. Stop by to check on our work.
July 2017 - Congratulations to Nihar on the filing of a provisional patent on our work to develop drugs for neurodegenerative diseases in collaboration with the Boustany lab!
June 2017 - Congratulations to both Verma and Bader who not only were selected to give podium presentations at the 2017 TTUHSC School of Pharmacy Research Days on their anti-cancer drug discovery research, but were also awarded travel scholarships as two of the three best presenters!
June 2017 - The group's research was presented at international, national and local meetings around the US in the week of June 12th; Paul delivered a seminar on our AKR1C3 research at the World Preclinical Congress, Mastering Medicinal Chemistry Session in Boston, Nihar presented our research to discover novel compounds to treat neurodegenerative diseases at the 2017 Bio-Organic Chemistry Gordon Conference in New Hampshire, both Verma and Bader were selected as podium presenters at the 2017 TTUHSC School of Pharmacy Research Days in Amarillo and Ahmed presented his work on Alzheimer's Disease Drug Discovery as a poster.
June 2017 - Congratulations to Verma! He has been awarded an ACS Division of Medicinal Chemistry Travel Award to present our AKR1C3 inhibitor research at the Fall Meeting in Washington D.C.
May 2017 - Congratulations to Hezhen and Bader (ably assisted by Verma and Nihar) who's work on the synthesis and anticancer effects of potent mitochondrial complex II inhibitors (succinate dehydrogenase inhibitors) has been accepted for publication in ChemMedChem! See our publications page for more details.
May 2017 - Paul was recently interviewed for the Pharmaceutical Journal (the professional publication of the Royal Pharmaceutical Society) about the challenges of designing therapeutic small molecules that can penetrate the brain. See the full article online now entitled 'A barrier to progress: getting drugs to the brain' Pharm J. Vol. 298, No 7901 online. DOI: 10.1211/PJ.2017.20202723.
Mar 2017 - Congratulations to Verma who has been accepted into the NCI Graduate Student Recruiting Program! This program invites outstanding graduate students to the NIH NCI campus for a three day event aimed at recruiting to postdoctoral positions at the NCI.
Feb 2017 - Congratulations to Verma who's work in collaboration with the Penning lab at The University of Pennsylvania School of Medicine, on the design of highly selective AKR1C3 inhibitors, is the subject of a newly filed provisional patent application. This is our second provisional patent application in three months! If your intrested in commercialization opportunities in this area feel free to email Paul or talk with Techs' Office of Research Commercialization. Check out the publications page for more details.
Jan 2017 - Our first provisional patent has been filed! Entiled 'Potent and selective peroxisome proliferator-activated receptor beta/delta agonists' the filing covers the synthesis and neuroprotective activity of novel composition of matter in collaboration with the Webb group at Houston Methodist Hospital Research Institute. If your intrested in commercialization opportunities in this area feel free to email Paul or talk with Techs' Office of Research Commercialization. Check out the publications page for more details.
Nov 2016 - Congratulations to Paul who has received the President's Early Career Investigator Award from Texas Tech!
Oct 2016 - Congratulations to Nihar who's paper detailing how passage variation in PC12 cells influences cell death has been accepted into ACS Chemical Neuroscience! See our publications page for more details.
Sep 2016 - Thank you to CPRIT for renewal funding of the Core Facilities Support Award 'North Texas Clinical Pharmacology Cancer Core' on which Paul is a Co-Investigator. Thank you CPRIT!
Sep 2016 - Paul will be presenting our progress on target discovery for Batten Disease at the Strategies for Tackling Rare Genetic Diseases symposium at the 14th Annual Discovery on Target Conference in Boston. If your at the conference stop by and hear the exciting progress we are making.
Aug 2016 - Two projects from the lab are being presented at the 252nd ACS National Meeting in Philadelphia, stop by and check out our progress.
Aug 2016 - Ahmed Morsy who completed a ABRI internship in the lab over the summer has joined us full time as a graduate student funded by the Texas Alzheimer's Research and Care Consortium. Welcome Ahmed.
July 2016 - The group is awarded a grant from Leukemia Texas to continue development and evaluation of AKR1C3 inhibitors for the treatment of leukemia. Thank you Leukemia Texas!
June 2016 - Congratulations to Verma who's paper on selective AKR1C3 inhibitors potentiating chemotherapeutic activity in Acute Myeloid Leukemia is accepted into ACS Medicinal Chemistry Letters! See our publication page for more details.
June 2016 - Welcome to Ahmed Morsy who joins the lab as a summer intern funded by the ABRI program.
June 2016 - Congratulations and good luck to Hezhen who has accepted a job at the FDA and will move to DC in June.
June 2016 - Congratulations to Nihar who has been chosen to present a podium presentation on our Batten disease project at the TTUHSC School of Pharmacy Research Days on June 2nd.
May 2016 - Our review on optimizing physicochemical properties of bioactive small molecules to enter the brain has been published in Current Medicinal Chemistry. See our publication page for more details.
May 2016 - Congratulations to Verma who was awarded the American Association of Pharmaceutical Sciences Biotechnology Student Research Award sponsored by Eli Lilly and Company and will present a podium presentation at the 2016 AAPS National Biotechnology Conference in Boston on his research developing AKR1C3 inhibitors for the treatment of leukemia and prostate cancer. His work was featured on the AAPS blog.
Mar 2016 - Congratulations to Nihar who's paper on PPAR β/δ agonists is published in Bioorganic and Medicinal Chemistry Letters! See our publication page for more details.
Mar 2016 - Paul is Guest Editor for a thematic issue of Mini Reviews in Medicinal Chemistry covering 'Small Molecule Drug Discovery for Pediatric Diseases'. Read the editorial on our publications page or see the full issue here.
Feb 2016 - Congratulations to Nihar who has been awarded a Dean's Scholarship by Texas Tech! He was one of only two students in the Graduate School of Pharmaceutical Sciences to receive the scholarship.
Jan 2016 - Congratulations to Nihar who has been awarded an Outstanding Young Investigator Scholarship from the Alzheimer's Drug Discovery Foundation to attend the 10th Annual Drug Discovery in Neurodegeneration Conference in Miami, FL! Nihar will present our work on identification of small molecules for the potential treatment of Batten Disease.
Jan 2016 - Welcome to Bader Huwaimel who joins the group as a graduate student funded by a grant from the Saudi Arabian Government.
Dec 2015 - Paul is invited to present a talk on the group's research at the TTUHSC Drug Discovery and Development mini-symposium in Lubbock.
Nov 2015 - Congratulations to Nihar on the publication of his paper in the Journal of Medicinal Chemistry reviewing small molecules and their mechanism of action for the treatment of Batten disease! More details on the publication page.
Nov 2015 - Paul is invited to present a talk on our AML research in the 'Natural Products: Tomorrow's Therapeutics' session at the joint Southeastern and Southwestern ACS Regional Meeting in Memphis, TN. Thank you to the Chemical Biology & Therapeutics Department at St Jude Children's Research Hospital for organizing and hosting.
Oct 2015 - The group is awarded a grant from the Texas Alzheimer's Research and Care Consortium to develop small molecule protein-protein interaction inhibitors for evaluation as a potential treatment for Alzheimer's Disease. Thank you TARCC!
Sep 2015 - Both Verma and Nihar pass their qualifying exams and advance to Ph.D. candidacy. Congratulations Nihar and Verma!
Sep 2015 - Congratulations to Verma who has been awarded a prestigious Mary Lou Clements-Mann scholarship from Texas Tech!
Aug 2015 - The group receives a grant to utilize CDD Vault with CDD Vision software as part of our drug discovery research from the BeHEARD Challenge. Thank you Rare Genomics Institute and Collaborative Drug Discovery!
Jul 2015 - Congratulations to Hezhen who's abstract from the International Chemical Biology Society Meeting is published in Assay and Drug Development Technologies! More details on the publication page.
May 2015 - Welcome to Kaeli Faires and Bryan Yu who will be conducting research in the lab over the summer. Kaeli is an Honors student at Texas Tech and Bryan is a pharmacy student at TTUHSC.
Apr 2015 - Congratulations to Juan who was awarded a TTUHSC ABRI Internship to stay with us and continue his research over the summer!
Mar 2015 - Kshitij and Nihar present posters describing their work in the Medicinal Chemistry Division at the 249th ACS National Meeting in Denver, CO.
Jan 2015 - Paul is selected to participate in the NIH Center for Scientific Review Early Career Reviewer Program.
Jan 2015 - The group receives a Center for Translational Medicine Pilot Program Grant! Thank you NIH/NCATS!
Jan 2015 - Congratulations to Kshitij on the publication of his manuscript in Chemico-Biological Interactions! The paper details our AKR1C3 inhibitor identification project in collaboration with the Penning Lab at The University of Pennsylvania. See our publication page for more details.
Nov 2014 - Our Complex II inhibitor project is presented at two meetings in California. Hezhen presents our work on Complex II inhibitors as novel anticancer agents at the American Association of Pharmaceutical Scientists Annual Meeting in San Diego and Paul presents our work on the development of Complex II inhibitor small molecule probes at the International Chemical Biology Society Meeting in San Francisco.
Oct 2014 - Welcome to Juan and Esther, P1 Pharmacy students who have joined the group.
Aug 2014 - Congratulations to Nihar on the publication of his paper in Tetrahedron Letters! See our publications page for more details.
July 2014 - The group is awarded two equipment grants: An Organic Purification Grant from Teledyne ISCO, and A TTUHSC Small Equipment Grant! The two grants will be combined to purchase a Teledyne Combiflash Rf200 Automated Flash Chromatography system for the lab. Thank you Teledyne ISCO and TTUHSC!
June 2014 - Verma is awarded a prize for Outstanding Poster Presentation by a Junior Graduate Student at the Thirteenth Annual School of Pharmacy Research Days! Congratulations Verma!
May 2014 - Jessica Mayo, a Baylor University Undergraduate, joins the lab as an Amarillo Biomedical Research Intern. Welcome Jessica!
May 2014 - Hezhen is selected to deliver a podium presentation detailing his ongoing research at the School of Pharmacy Research Days. Congratulations Hezhen!
Apr 2014 - Dr. Milton Brown, the Director of the Center for Drug Discovery and Development at Georgetown University Medical Center will present a seminar entitled 'Discovery of HDAC Inhibitors as Radiation Sensitizers and Anti-cancer agents' on April 23rd as the Department Distinguished Speaker, organized by Dr. Trippier.
Mar 2014 - The installation of our Gilson preparative HPLC is completed, take a look at the photos section to see it in operation.
Feb 2014 - Paul attends the NIH organized Training in Neurotherapeutics Discovery and Development for Academic Scientists Course in Bethesda, MD.
Nov 2013 - The group is awarded an equipment grant from The Gilson Program to Accelerate the Sciences! Thank you Gilson.
Aug 2013 - Nihar Kinarivala joins us as a new graduate student. Welcome Nihar!
Jul 2013 - Our first Pharm.D student joins the lab! Welcome Peter
May 2013 - Our first graduate student joins the lab! Welcome Verma!
May 2013 - Dr. Hezhen Wang joins the lab as a Research Associate. Welcome Hezhen!
Apr 2013 - Paul is part of the team awarded both the Class of 2016 and Graduate Student Teaching Team of the Year Award 2013! Thanks everyone who voted!
Feb 2013 - The Trippier lab is the recipient of a Kimax lab start up grant, thank you Kimble Chase!
Jan 2013 - The first publication from the new lab, a review on biotinylating small molecules, is published in the journal ChemMedChem.
Jan 2013 - We finally have a group website!
Sep 2012 - A new group is born at TTUHSC School of Pharmacy